1khc

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[[Image:1khc.png|left|200px]]
 
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{{STRUCTURE_1khc| PDB=1khc | SCENE= }}
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==Crystal Structure of the PWWP Domain of Mammalian DNA Methyltransferase Dnmt3b==
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<StructureSection load='1khc' size='340' side='right'caption='[[1khc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal Structure of the PWWP Domain of Mammalian DNA Methyltransferase Dnmt3b===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1khc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KHC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11836534}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1khc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1khc OCA], [https://pdbe.org/1khc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1khc RCSB], [https://www.ebi.ac.uk/pdbsum/1khc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1khc ProSAT]</span></td></tr>
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[[1khc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3B_MOUSE DNM3B_MOUSE] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).<ref>PMID:10555141</ref> <ref>PMID:11919202</ref> <ref>PMID:16567415</ref> <ref>PMID:18056424</ref> <ref>PMID:18567530</ref> <ref>PMID:11836534</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/1khc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1khc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA methyltransferase|DNA methyltransferase]]
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011836534</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, X.]]
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[[Category: Cheng X]]
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[[Category: Qiu, C.]]
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[[Category: Qiu C]]
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[[Category: Sawada, K.]]
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[[Category: Sawada K]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Five beta-sheets barrel followed by five-helix bundle]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the PWWP Domain of Mammalian DNA Methyltransferase Dnmt3b

PDB ID 1khc

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