This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1kuv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:27, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1kuv.png|left|200px]]
 
-
{{STRUCTURE_1kuv| PDB=1kuv | SCENE= }}
+
==X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition==
-
 
+
<StructureSection load='1kuv' size='340' side='right'caption='[[1kuv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
===X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1kuv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KUV FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11902838}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA5:COA-S-ACETYL+5-BROMOTRYPTAMINE'>CA5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kuv OCA], [https://pdbe.org/1kuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kuv RCSB], [https://www.ebi.ac.uk/pdbsum/1kuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kuv ProSAT]</span></td></tr>
-
[[1kuv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SNAT_SHEEP SNAT_SHEEP] Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.<ref>PMID:15644438</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/1kuv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kuv ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
*[[Serotonin N-acetyltransferase|Serotonin N-acetyltransferase]]
*[[Serotonin N-acetyltransferase|Serotonin N-acetyltransferase]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:011902838</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Aralkylamine N-acetyltransferase]]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
-
[[Category: Angelis, J De.]]
+
[[Category: Burley SK]]
-
[[Category: Burley, S K.]]
+
[[Category: Cole PA]]
-
[[Category: Cole, P A.]]
+
[[Category: De Angelis J]]
-
[[Category: Khalil, E M.]]
+
[[Category: Khalil EM]]
-
[[Category: Wolf, E.]]
+
[[Category: Wolf E]]
-
[[Category: Alternate conformation]]
+
-
[[Category: Bisubstrate analog]]
+
-
[[Category: Enzyme-inhibitor complex]]
+
-
[[Category: Transferase]]
+

Current revision

X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition

PDB ID 1kuv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kuv"
Personal tools