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1l1e

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[[Image:1l1e.png|left|200px]]
 
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{{STRUCTURE_1l1e| PDB=1l1e | SCENE= }}
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==Crystal Structure of Mycolic Acid Cyclopropane Synthase PcaA Complexed with S-adenosyl-L-homocysteine==
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<StructureSection load='1l1e' size='340' side='right'caption='[[1l1e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of Mycolic Acid Cyclopropane Synthase PcaA Complexed with S-adenosyl-L-homocysteine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11756461}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1e OCA], [https://pdbe.org/1l1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1e RCSB], [https://www.ebi.ac.uk/pdbsum/1l1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1e ProSAT], [https://www.topsan.org/Proteins/TBSGC/1l1e TOPSAN]</span></td></tr>
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[[1l1e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1E OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CMAS3_MYCTU CMAS3_MYCTU] Involved in the phagosome maturation block (PMB). Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. It can use cis, cis 11,14-eicosadienoic acid and linoelaidic acid as substrate. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:10882107</ref> <ref>PMID:22621931</ref>
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<ref group="xtra">PMID:011756461</ref><ref group="xtra">PMID:012462144</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1e ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Glickman, M S.]]
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[[Category: Glickman MS]]
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[[Category: Huang, C C.]]
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[[Category: Huang C-C]]
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[[Category: Jacobs, W R.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Smith, C V.]]
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[[Category: Smith CV]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Alpha/beta]]
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[[Category: Methyltransferase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: S-adenosyl-l-homocysteine cofactor]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Mycolic Acid Cyclopropane Synthase PcaA Complexed with S-adenosyl-L-homocysteine

PDB ID 1l1e

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