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1l8k

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T Cell Protein-Tyrosine Phosphatase Structure

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l8k"

Categories: Homo sapiens | Large Structures | Iversen LF

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-[[Image:1l8k.gif|left|200px]]<br />
-<applet load="1l8k" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1l8k, resolution 2.56&Aring;" />
-'''T Cell Protein-Tyrosine Phosphatase Structure'''<br />
-==Overview==
+==T Cell Protein-Tyrosine Phosphatase Structure==
-Protein-tyrosine phosphatase 1B (PTP1B) has recently received much, attention as a potential drug target in type 2 diabetes. This has in, particular been spurred by the finding that PTP1B knockout mice show, increased insulin sensitivity and resistance to diet-induced obesity., Surprisingly, the highly homologous T cell protein-tyrosine phosphatase, (TC-PTP) has received much less attention, and no x-ray structure has been, provided. We have previously co-crystallized PTP1B with a number of low, molecular weight inhibitors that inhibit TC-PTP with similar efficiency., Unexpectedly, we were not able to co-crystallize TC-PTP with the same set, of inhibitors. This seems to be due to a multimerization process where, residues 130-132, the DDQ loop, from one molecule is inserted into the, active site of the neighboring molecule, resulting in a continuous string, of interacting TC-PTP molecules. Importantly, despite the high degree of, functional and structural similarity between TC-PTP and PTP1B, we have, been able to identify areas close to the active site that might be, addressed to develop selective inhibitors of each enzyme.
+<StructureSection load='1l8k' size='340' side='right'caption='[[1l8k]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1l8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8K FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8k OCA], [https://pdbe.org/1l8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8k RCSB], [https://www.ebi.ac.uk/pdbsum/1l8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8k ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN2_HUMAN PTN2_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8k ConSurf].
+<div style="clear:both"></div>
-==Disease==
+==See Also==
-Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]], Rheumatoid arthritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]], Systemic lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-L8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1L8K OCA].
-==Reference==
-Structure determination of T cell protein-tyrosine phosphatase., Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NP, J Biol Chem. 2002 May 31;277(22):19982-90. Epub 2002 Mar 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11907034 11907034]
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Iversen LF]]
-[[Category: Iversen, L.F.]]
-[[Category: protein tyrosine phosphatase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:57:43 2007''

1l8k

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T Cell Protein-Tyrosine Phosphatase Structure

Structural highlights

Function

Evolutionary Conservation

See Also

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