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1lio

From Proteopedia

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{{Seed}}
 
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[[Image:1lio.png|left|200px]]
 
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==STRUCTURE OF APO T. GONDII ADENOSINE KINASE==
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The line below this paragraph, containing "STRUCTURE_1lio", creates the "Structure Box" on the page.
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<StructureSection load='1lio' size='340' side='right'caption='[[1lio]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dh2 1dh2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LIO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lio OCA], [https://pdbe.org/1lio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lio RCSB], [https://www.ebi.ac.uk/pdbsum/1lio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lio ProSAT]</span></td></tr>
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{{STRUCTURE_1lio| PDB=1lio | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADK_TOXGO ADK_TOXGO] ATP-dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. It is a key purine metabolic enzyme in the opportunistic parasitic protozoan toxoplasma gondii as it cannot synthesize purines de novo.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/1lio_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lio ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF APO T. GONDII ADENOSINE KINASE===
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==See Also==
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*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10801355}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10801355 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10801355}}
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==About this Structure==
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1LIO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dh2 1dh2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIO OCA].
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==Reference==
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Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding., Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG, J Mol Biol. 2000 May 19;298(5):875-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10801355 10801355]
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[[Category: Adenosine kinase]]
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[[Category: Single protein]]
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[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Brennan, R G.]]
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[[Category: Brennan RG]]
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[[Category: Ealick, S E.]]
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[[Category: Ealick SE]]
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[[Category: Matthews, I I.]]
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[[Category: Mathews II]]
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[[Category: Schumacher, M A.]]
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[[Category: Schumacher MA]]
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[[Category: Scott, D M.]]
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[[Category: Scott DM]]
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[[Category: Alpha-beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:11 2008''
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Current revision

STRUCTURE OF APO T. GONDII ADENOSINE KINASE

PDB ID 1lio

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