1lw3

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{{Seed}}
 
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[[Image:1lw3.png|left|200px]]
 
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==Crystal Structure of Myotubularin-related protein 2 complexed with phosphate==
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The line below this paragraph, containing "STRUCTURE_1lw3", creates the "Structure Box" on the page.
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<StructureSection load='1lw3' size='340' side='right'caption='[[1lw3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LW3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1lw3| PDB=1lw3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lw3 OCA], [https://pdbe.org/1lw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1lw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lw3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN] Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:[https://omim.org/entry/601382 601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.<ref>PMID:10802647</ref> <ref>PMID:12398840</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN] Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.<ref>PMID:12668758</ref> <ref>PMID:21372139</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/1lw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lw3 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Myotubularin-related protein 2 complexed with phosphate===
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==See Also==
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14690594}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14690594 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_14690594}}
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==Disease==
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Known disease associated with this structure: Charcot-Marie-Tooth disease, type 4B1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603557 603557]]
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==About this Structure==
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1LW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LW3 OCA].
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==Reference==
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Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome., Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA, Mol Cell. 2003 Dec;12(6):1391-402. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14690594 14690594]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol-3-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Begley MJ]]
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[[Category: Begley, M J.]]
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[[Category: Dixon JE]]
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[[Category: Dixon, J E.]]
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[[Category: Kim S-A]]
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[[Category: Kim, S A.]]
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[[Category: Stuckey JA]]
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[[Category: Stuckey, J A.]]
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[[Category: Taylor GS]]
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[[Category: Taylor, G S.]]
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[[Category: Veine DM]]
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[[Category: Veine, D M.]]
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[[Category: Protein-phosphate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:35:35 2008''
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Current revision

Crystal Structure of Myotubularin-related protein 2 complexed with phosphate

PDB ID 1lw3

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