1m1c

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{{Seed}}
 
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[[Image:1m1c.png|left|200px]]
 
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==Structure of the L-A virus==
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The line below this paragraph, containing "STRUCTURE_1m1c", creates the "Structure Box" on the page.
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<StructureSection load='1m1c' size='340' side='right'caption='[[1m1c]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_virus_L-A Saccharomyces cerevisiae virus L-A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1c OCA], [https://pdbe.org/1m1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1c RCSB], [https://www.ebi.ac.uk/pdbsum/1m1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1c ProSAT]</span></td></tr>
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{{STRUCTURE_1m1c| PDB=1m1c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_SCVLA GAG_SCVLA] Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 40 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref> Binds and removes 5' cap structures from cellular mRNA. Forms a covalent bond with m7GMP through His-154 of the capsid protein while releasing the mRNA body.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1c ConSurf].
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<div style="clear:both"></div>
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===Structure of the L-A virus===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12244300 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12244300}}
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[[Category: Saccharomyces cerevisiae virus L-A]]
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[[Category: Canady M]]
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==About this Structure==
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[[Category: Johnson JE]]
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1M1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA].
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[[Category: Naitow H]]
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[[Category: Tang J]]
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==Reference==
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[[Category: Wickner RB]]
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L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism., Naitow H, Tang J, Canady M, Wickner RB, Johnson JE, Nat Struct Biol. 2002 Oct;9(10):725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12244300 12244300]
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[[Category: Single protein]]
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[[Category: Viruses]]
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[[Category: Canady, M.]]
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[[Category: Johnson, J E.]]
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[[Category: Naitow, H.]]
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[[Category: Tang, J.]]
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[[Category: Wickner, R B.]]
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[[Category: Dsrna virus structure]]
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[[Category: Icosahedral virus]]
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[[Category: L-a virus]]
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[[Category: Mrna decapping]]
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[[Category: Quai-equivalence]]
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[[Category: Rna-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:00:08 2008''
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Current revision

Structure of the L-A virus

PDB ID 1m1c

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