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1m1k

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[[Image:1m1k.png|left|200px]]
 
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{{STRUCTURE_1m1k| PDB=1m1k | SCENE= }}
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==Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui==
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<StructureSection load='1m1k' size='340' side='right'caption='[[1m1k]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m1k]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12150912}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZIT:AZITHROMYCIN'>ZIT</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1k OCA], [https://pdbe.org/1m1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1k RCSB], [https://www.ebi.ac.uk/pdbsum/1m1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1k ProSAT]</span></td></tr>
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[[1m1k]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL3_HALMA RL3_HALMA] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).[HAMAP-Rule:MF_01325_A]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1k ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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__TOC__
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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</StructureSection>
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*[[Ribosomal protein L15|Ribosomal protein L15]]
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*[[Ribosomal protein L18|Ribosomal protein L18]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L22|Ribosomal protein L22]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L30|Ribosomal protein L30]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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*[[User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin|User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin]]
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==Reference==
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<ref group="xtra">PMID:012150912</ref><references group="xtra"/>
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Ban, N.]]
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[[Category: Large Structures]]
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[[Category: Hansen, J L.]]
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[[Category: Ban N]]
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[[Category: Ippolito, J A.]]
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[[Category: Hansen JL]]
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[[Category: Moore, P B.]]
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[[Category: Ippolito JA]]
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[[Category: Nissen, P.]]
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[[Category: Moore PB]]
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[[Category: Steitz, T A.]]
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[[Category: Nissen P]]
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[[Category: 50]]
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[[Category: Steitz TA]]
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[[Category: Azithromycin]]
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[[Category: Haloarcula]]
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[[Category: Macrolide]]
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[[Category: Ribosome]]
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Current revision

Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui

PDB ID 1m1k

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