1m6u

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{{Seed}}
 
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[[Image:1m6u.png|left|200px]]
 
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==Crystal Structure of a Novel DNA-binding domain from Ndt80, a Transcriptional Activator Required for Meiosis in Yeast==
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The line below this paragraph, containing "STRUCTURE_1m6u", creates the "Structure Box" on the page.
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<StructureSection load='1m6u' size='340' side='right'caption='[[1m6u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M6U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1m6u| PDB=1m6u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6u OCA], [https://pdbe.org/1m6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m6u RCSB], [https://www.ebi.ac.uk/pdbsum/1m6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m6u ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of a Novel DNA-binding domain from Ndt80, a Transcriptional Activator Required for Meiosis in Yeast===
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== Function ==
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[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12384578 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m6u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12384578}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1M6U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m6u ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast., Montano SP, Cote ML, Fingerman I, Pierce M, Vershon AK, Georgiadis MM, Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14041-6. Epub 2002 Oct 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12384578 12384578]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Cote ML]]
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[[Category: Cote, M L.]]
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[[Category: Fingerman I]]
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[[Category: Fingerman, I.]]
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[[Category: Georgiadis MM]]
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[[Category: Georgiadis, M M.]]
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[[Category: Montano SP]]
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[[Category: Montano, S P.]]
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[[Category: Pierce M]]
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[[Category: Pierce, M.]]
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[[Category: Vershon AK]]
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[[Category: Vershon, A K.]]
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[[Category: Dna-binding]]
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[[Category: Meiosis]]
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[[Category: Transcription activator]]
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[[Category: Yeast protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:20:29 2008''
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Current revision

Crystal Structure of a Novel DNA-binding domain from Ndt80, a Transcriptional Activator Required for Meiosis in Yeast

PDB ID 1m6u

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