1m8h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:41, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m8h.png|left|200px]]
 
-
<!--
+
==inducible nitric oxide synthase with 6-nitroindazole bound==
-
The line below this paragraph, containing "STRUCTURE_1m8h", creates the "Structure Box" on the page.
+
<StructureSection load='1m8h' size='340' side='right'caption='[[1m8h]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1m8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NI:6-NITROINDAZOLE'>6NI</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1m8h| PDB=1m8h | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8h OCA], [https://pdbe.org/1m8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8h RCSB], [https://www.ebi.ac.uk/pdbsum/1m8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8h ProSAT]</span></td></tr>
-
 
+
</table>
-
===inducible nitric oxide synthase with 6-nitroindazole bound===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_12437348}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12437348 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8h_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_12437348}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[1m8h]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8H OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8h ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Nitric Oxide Synthase]]
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:012437348</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Aberg A]]
-
[[Category: Aberg, A.]]
+
[[Category: Andersson G]]
-
[[Category: Andersson, G.]]
+
[[Category: Garcin ED]]
-
[[Category: Garcin, E D.]]
+
[[Category: Getzoff ED]]
-
[[Category: Getzoff, E D.]]
+
[[Category: Panda K]]
-
[[Category: Panda, K.]]
+
[[Category: Rosenfeld RJ]]
-
[[Category: Rosenfeld, R J.]]
+
[[Category: Stuehr DJ]]
-
[[Category: Stuehr, D J.]]
+
[[Category: Tainer JA]]
-
[[Category: Tainer, J A.]]
+
[[Category: Wallace AV]]
-
[[Category: Wallace, A V.]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

inducible nitric oxide synthase with 6-nitroindazole bound

PDB ID 1m8h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m8h"
Personal tools