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1mho

From Proteopedia

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[[Image:1mho.png|left|200px]]
 
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{{STRUCTURE_1mho| PDB=1mho | SCENE= }}
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==THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN==
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<StructureSection load='1mho' size='340' side='right'caption='[[1mho]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mho OCA], [https://pdbe.org/1mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mho RCSB], [https://www.ebi.ac.uk/pdbsum/1mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mho ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mho_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mho ConSurf].
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<div style="clear:both"></div>
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===THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN===
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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{{ABSTRACT_PUBMED_9519413}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHO OCA].
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Harada, S.]]
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[[Category: Large Structures]]
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[[Category: Inoue, T.]]
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[[Category: Harada S]]
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[[Category: Matsumura, H.]]
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[[Category: Inoue T]]
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[[Category: Shiba, T.]]
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[[Category: Matsumura H]]
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[[Category: Yasushi, K A.I.]]
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[[Category: Shiba T]]
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[[Category: Calcium-binding]]
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[[Category: Yasushi KAI]]
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[[Category: Metal-binding]]
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Current revision

THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN

PDB ID 1mho

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