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1mq7

From Proteopedia

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{{Seed}}
 
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[[Image:1mq7.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF DUTPASE FROM MYCOBACTERIUM TUBERCULOSIS (RV2697C)==
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The line below this paragraph, containing "STRUCTURE_1mq7", creates the "Structure Box" on the page.
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<StructureSection load='1mq7' size='340' side='right'caption='[[1mq7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_1mq7| PDB=1mq7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq7 OCA], [https://pdbe.org/1mq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq7 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq7 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF DUTPASE FROM MYCOBACTERIUM TUBERCULOSIS (RV2697C)===
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==See Also==
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15276840}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15276840 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15276840}}
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==About this Structure==
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1MQ7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ7 OCA].
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==Reference==
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Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism., Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CM, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, Sawaya MR, J Mol Biol. 2004 Aug 6;341(2):503-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15276840 15276840]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Chan S]]
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[[Category: DUTP diphosphatase]]
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[[Category: Cho US]]
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[[Category: Chan, S.]]
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[[Category: Eisenberg D]]
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[[Category: Cho, U S.]]
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[[Category: Heike K]]
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[[Category: Eisenberg, D.]]
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[[Category: Lekin T]]
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[[Category: Heike, K.]]
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[[Category: Naranjo C]]
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[[Category: Lekin, T.]]
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[[Category: Perry LJ]]
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[[Category: Naranjo, C.]]
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[[Category: Sawaya MR]]
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[[Category: Perry, L J.]]
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[[Category: Segelke BW]]
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[[Category: Sawaya, M R.]]
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[[Category: Yeates TO]]
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[[Category: Segelke, B W.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Yeates, T O.]]
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[[Category: Jelly-roll]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:51:57 2008''
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Current revision

CRYSTAL STRUCTURE OF DUTPASE FROM MYCOBACTERIUM TUBERCULOSIS (RV2697C)

PDB ID 1mq7

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