1mrq

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[[Image:1mrq.png|left|200px]]
 
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{{STRUCTURE_1mrq| PDB=1mrq | SCENE= }}
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==Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone==
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<StructureSection load='1mrq' size='340' side='right'caption='[[1mrq]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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===Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mrq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MRQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12899831}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrq OCA], [https://pdbe.org/1mrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mrq RCSB], [https://www.ebi.ac.uk/pdbsum/1mrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrq ProSAT]</span></td></tr>
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[[1mrq]] is a 1 chain structure of [[Hydroxysteroid dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRQ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AK1C1_HUMAN AK1C1_HUMAN] Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.<ref>PMID:11013348</ref> <ref>PMID:8573067</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mrq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mrq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012899831</ref><references group="xtra"/>
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__TOC__
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[[Category: 20-alpha-hydroxysteroid dehydrogenase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Breton, R.]]
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[[Category: Large Structures]]
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[[Category: Cantin, L.]]
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[[Category: Breton R]]
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[[Category: Couture, J F.]]
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[[Category: Cantin L]]
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[[Category: Labrie, F.]]
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[[Category: Couture JF]]
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[[Category: Legrand, P.]]
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[[Category: Labrie F]]
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[[Category: Luu-The, V.]]
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[[Category: Legrand P]]
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[[Category: 20alpha-hsd]]
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[[Category: Luu-The V]]
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[[Category: Hydroxysteroid dehydrogenase]]
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[[Category: Oxidoreductase]]
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[[Category: Progesterone]]
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[[Category: Ternary complex]]
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Current revision

Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone

PDB ID 1mrq

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