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1mto

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[[Image:1mto.png|left|200px]]
 
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{{STRUCTURE_1mto| PDB=1mto | SCENE= }}
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==Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate==
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<StructureSection load='1mto' size='340' side='right'caption='[[1mto]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mto]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MTO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12390023}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mto OCA], [https://pdbe.org/1mto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mto RCSB], [https://www.ebi.ac.uk/pdbsum/1mto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mto ProSAT]</span></td></tr>
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[[1mto]] is a 8 chain structure of [[Phosphofructokinase (PFK)]] with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PFKA_GEOSE PFKA_GEOSE] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_00339]<ref>PMID:8136379</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/1mto_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mto ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012390023</ref><references group="xtra"/>
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__TOC__
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[[Category: 6-phosphofructokinase]]
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</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Reinhart, G D.]]
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[[Category: Large Structures]]
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[[Category: Riley-Lovingshimer, M R.]]
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[[Category: Reinhart GD]]
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[[Category: Ronning, D R.]]
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[[Category: Riley-Lovingshimer MR]]
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[[Category: Sacchettini, J C.]]
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[[Category: Ronning DR]]
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[[Category: Fructose-6-phosphate]]
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[[Category: Sacchettini JC]]
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[[Category: Phosphofructokinase]]
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[[Category: Transferase]]
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[[Category: Tryptophan-shift]]
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Current revision

Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate

PDB ID 1mto

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