1n11

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[[Image:1n11.png|left|200px]]
 
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==D34 REGION OF HUMAN ANKYRIN-R AND LINKER==
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The line below this paragraph, containing "STRUCTURE_1n11", creates the "Structure Box" on the page.
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<StructureSection load='1n11' size='340' side='right'caption='[[1n11]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N11 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1n11| PDB=1n11 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n11 OCA], [https://pdbe.org/1n11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n11 RCSB], [https://www.ebi.ac.uk/pdbsum/1n11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n11 ProSAT]</span></td></tr>
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</table>
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===D34 REGION OF HUMAN ANKYRIN-R AND LINKER===
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== Disease ==
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[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:[https://omim.org/entry/182900 182900]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive.<ref>PMID:8640229</ref> <ref>PMID:11102985</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN] Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.<ref>PMID:12456646</ref> Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:12456646</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_12456646}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 12456646 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_12456646}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n11_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[1n11]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N11 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n11 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Group:MUZIC:CARP]]
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*[[Ankyrin|Ankyrin]]
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*[[User:Narendra Kumar Verma]]
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*[[Ankyrin 3D structures|Ankyrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012456646</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, R G.W.]]
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[[Category: Large Structures]]
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[[Category: Machius, M.]]
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[[Category: Anderson RGW]]
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[[Category: Michaely, P.]]
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[[Category: Machius M]]
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[[Category: Tomchick, D R.]]
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[[Category: Michaely P]]
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[[Category: Anion exchanger]]
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[[Category: Tomchick DR]]
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[[Category: Ankyrin]]
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[[Category: Band 3]]
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[[Category: Clathrin]]
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[[Category: Structural protein]]
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Current revision

D34 REGION OF HUMAN ANKYRIN-R AND LINKER

PDB ID 1n11

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