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1n4g

From Proteopedia

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{{Seed}}
 
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[[Image:1n4g.png|left|200px]]
 
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==Structure of CYP121, a Mycobacterial P450, in Complex with Iodopyrazole==
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The line below this paragraph, containing "STRUCTURE_1n4g", creates the "Structure Box" on the page.
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<StructureSection load='1n4g' size='340' side='right'caption='[[1n4g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n4g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PYZ:4-IODOPYRAZOLE'>PYZ</scene></td></tr>
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{{STRUCTURE_1n4g| PDB=1n4g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4g OCA], [https://pdbe.org/1n4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4g RCSB], [https://www.ebi.ac.uk/pdbsum/1n4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP121_MYCTU CP121_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4g ConSurf].
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<div style="clear:both"></div>
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===Structure of CYP121, a Mycobacterial P450, in Complex with Iodopyrazole===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12435731}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12435731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12435731}}
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==About this Structure==
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1N4G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4G OCA].
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==Reference==
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Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450., Leys D, Mowat CG, McLean KJ, Richmond A, Chapman SK, Walkinshaw MD, Munro AW, J Biol Chem. 2003 Feb 14;278(7):5141-7. Epub 2002 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12435731 12435731]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Chapman SK]]
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[[Category: Chapman, S K.]]
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[[Category: Leys D]]
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[[Category: Leys, D.]]
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[[Category: McLean KJ]]
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[[Category: McLean, K J.]]
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[[Category: Mowat CG]]
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[[Category: Mowat, C G.]]
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[[Category: Munro AW]]
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[[Category: Munro, A W.]]
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[[Category: Richmond A]]
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[[Category: Richmond, A.]]
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[[Category: Walkinshaw MD]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Heme binding]]
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[[Category: Iodopyrazole complex]]
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[[Category: P450 fold]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:13:59 2008''
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Current revision

Structure of CYP121, a Mycobacterial P450, in Complex with Iodopyrazole

PDB ID 1n4g

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