1n4h

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[[Image:1n4h.gif|left|200px]]
 
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==Characterization of ligands for the orphan nuclear receptor RORbeta==
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The line below this paragraph, containing "STRUCTURE_1n4h", creates the "Structure Box" on the page.
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<StructureSection load='1n4h' size='340' side='right'caption='[[1n4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n4h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
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{{STRUCTURE_1n4h| PDB=1n4h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4h OCA], [https://pdbe.org/1n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4h RCSB], [https://www.ebi.ac.uk/pdbsum/1n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4h ProSAT]</span></td></tr>
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</table>
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'''Characterization of ligands for the orphan nuclear receptor RORbeta'''
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== Function ==
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[https://www.uniprot.org/uniprot/RORB_RAT RORB_RAT] Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Retinoids regulate gene expression through binding to the nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). In contrast, no ligands for the retinoic acid receptor-related orphan receptors beta and gamma (ROR beta and gamma) have been identified, yet structural data and structure-function analyses indicate that ROR beta is a ligand-regulated nuclear receptor. Using nondenaturing mass spectrometry and scintillation proximity assays we found that all-trans retinoic acid (ATRA) and several retinoids bind to the ROR beta ligand-binding domain (LBD). The crystal structures of the complex with ATRA and with the synthetic analog ALRT 1550 reveal the binding modes of these ligands. ATRA and related retinoids inhibit ROR beta but not ROR alpha transcriptional activity suggesting that high-affinity, subtype-specific ligands could be designed for the identification of ROR beta target genes. Our results identify ROR beta as a retinoid-regulated nuclear receptor, providing a novel pathway for retinoid action.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4h_consurf.spt"</scriptWhenChecked>
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1N4H is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4H OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta., Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schule R, Nat Struct Biol. 2003 Oct;10(10):820-5. Epub 2003 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12958591 12958591]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4h ConSurf].
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[[Category: Protein complex]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Dorsselaer, A Van.]]
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[[Category: Moras D]]
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[[Category: Moras, D.]]
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[[Category: Renaud J-P]]
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[[Category: Renaud, J P.]]
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[[Category: Sanglier S]]
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[[Category: Sanglier, S.]]
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[[Category: Schuele R]]
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[[Category: Schuele, R.]]
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[[Category: Stehlin-Gaon C]]
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[[Category: Stehlin-Gaon, C.]]
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[[Category: Van Dorsselaer A]]
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[[Category: Willmann, D.]]
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[[Category: Willmann D]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Protein-peptide-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:05:02 2008''
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Current revision

Characterization of ligands for the orphan nuclear receptor RORbeta

PDB ID 1n4h

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