1n4h

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{{Seed}}
 
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[[Image:1n4h.png|left|200px]]
 
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==Characterization of ligands for the orphan nuclear receptor RORbeta==
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The line below this paragraph, containing "STRUCTURE_1n4h", creates the "Structure Box" on the page.
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<StructureSection load='1n4h' size='340' side='right'caption='[[1n4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n4h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
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{{STRUCTURE_1n4h| PDB=1n4h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4h OCA], [https://pdbe.org/1n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4h RCSB], [https://www.ebi.ac.uk/pdbsum/1n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4h ProSAT]</span></td></tr>
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</table>
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===Characterization of ligands for the orphan nuclear receptor RORbeta===
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== Function ==
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[https://www.uniprot.org/uniprot/RORB_RAT RORB_RAT] Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12958591 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4h_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12958591}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1N4H is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4H OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4h ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta., Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schule R, Nat Struct Biol. 2003 Oct;10(10):820-5. Epub 2003 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12958591 12958591]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Dorsselaer, A Van.]]
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[[Category: Moras D]]
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[[Category: Moras, D.]]
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[[Category: Renaud J-P]]
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[[Category: Renaud, J P.]]
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[[Category: Sanglier S]]
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[[Category: Sanglier, S.]]
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[[Category: Schuele R]]
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[[Category: Schuele, R.]]
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[[Category: Stehlin-Gaon C]]
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[[Category: Stehlin-Gaon, C.]]
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[[Category: Van Dorsselaer A]]
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[[Category: Willmann, D.]]
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[[Category: Willmann D]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Protein-peptide-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:57:14 2008''
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Current revision

Characterization of ligands for the orphan nuclear receptor RORbeta

PDB ID 1n4h

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