1n4h
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1n4h.png|left|200px]] | ||
| - | + | ==Characterization of ligands for the orphan nuclear receptor RORbeta== | |
| - | + | <StructureSection load='1n4h' size='340' side='right'caption='[[1n4h]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1n4h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4h OCA], [https://pdbe.org/1n4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4h RCSB], [https://www.ebi.ac.uk/pdbsum/1n4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4h ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/RORB_RAT RORB_RAT] Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. | |
| - | + | == Evolutionary Conservation == | |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4h_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | == | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4h ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | + | [[Category: Moras D]] | |
| - | [[Category: Moras | + | [[Category: Renaud J-P]] |
| - | [[Category: Renaud | + | [[Category: Sanglier S]] |
| - | [[Category: Sanglier | + | [[Category: Schuele R]] |
| - | [[Category: Schuele | + | [[Category: Stehlin-Gaon C]] |
| - | [[Category: Stehlin-Gaon | + | [[Category: Van Dorsselaer A]] |
| - | [[Category: | + | [[Category: Willmann D]] |
| - | [[Category: | + | |
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Current revision
Characterization of ligands for the orphan nuclear receptor RORbeta
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