1n4k

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{{Seed}}
 
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[[Image:1n4k.png|left|200px]]
 
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==Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3==
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The line below this paragraph, containing "STRUCTURE_1n4k", creates the "Structure Box" on the page.
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<StructureSection load='1n4k' size='340' side='right'caption='[[1n4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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{{STRUCTURE_1n4k| PDB=1n4k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4k OCA], [https://pdbe.org/1n4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4k RCSB], [https://www.ebi.ac.uk/pdbsum/1n4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4k ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3===
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==See Also==
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*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12442173}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12442173 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12442173}}
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==About this Structure==
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1N4K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4K OCA].
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==Reference==
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Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand., Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M, Nature. 2002 Dec 12;420(6916):696-700. Epub 2002 Nov 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12442173 12442173]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Alattia JR]]
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[[Category: Alattia, J R.]]
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[[Category: Bosanac I]]
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[[Category: Bosanac, I.]]
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[[Category: Chan J]]
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[[Category: Chan, J.]]
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[[Category: Furuichi T]]
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[[Category: Furuichi, T.]]
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[[Category: Ikura M]]
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[[Category: Ikura, M.]]
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[[Category: Iwai M]]
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[[Category: Iwai, M.]]
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[[Category: Mal TK]]
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[[Category: Mal, T K.]]
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[[Category: Michikawa T]]
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[[Category: Michikawa, T.]]
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[[Category: Mikoshiba K]]
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[[Category: Mikoshiba, K.]]
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[[Category: Talarico S]]
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[[Category: Talarico, S.]]
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[[Category: Tong FK]]
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[[Category: Tong, F K.]]
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[[Category: Tong KI]]
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[[Category: Tong, K I.]]
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[[Category: Yoshikawa F]]
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[[Category: Yoshikawa, F.]]
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[[Category: Armadillo-like fold]]
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[[Category: B-trefoil fold]]
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[[Category: Calcium channel,protein-ligand complex]]
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[[Category: Ip3 receptor]]
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[[Category: Ip3-binding core]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:51:23 2008''
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Current revision

Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3

PDB ID 1n4k

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OCA

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