1ndn

[[Image:1ndn.jpg|left|200px]]<br /><applet load="1ndn" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ndn, resolution 3.000&Aring;" />

'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''<br />

==Overview==

The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides, has been determined by x-ray diffraction analysis at 3 A resolution. The molecule adopts a B-DNA conformation, not unlike those found in intact dodecamer DNA molecules crystallized in a somewhat different crystal lattice, despite a gap due to the absence of a phosphate group in the molecule. The helix has a distinct narrow minor groove near the center of the molecule at the AAAA region. This suggests that the internal stabilizing forces due to base stacking and hydrogen-bonding interactions are sufficient to overcome the loss of connectivity associated with the disruption of the covalent backbone of DNA.

 

==About this Structure==

1NDN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].

 

==Reference==

Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2320572 2320572]

[[Category: Protein complex]]

[[Category: Aymani, J.]]

[[Category: Boom, J H.Van.]]

[[Category: Coll, M.]]

[[Category: Marel, G A.Van Der.]]

[[Category: Rich, A.]]

[[Category: Wang, A H.J.]]

[[Category: b-dna]]

[[Category: double helix]]

[[Category: nicked]]