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| - | [[Image:1ndn.jpg|left|200px]] | |
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| - | {{Structure
| + | ==MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4== |
| - | |PDB= 1ndn |SIZE=350|CAPTION= <scene name='initialview01'>1ndn</scene>, resolution 3.000Å
| + | <StructureSection load='1ndn' size='340' side='right'caption='[[1ndn]], [[Resolution|resolution]] 3.00Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>
| + | <table><tr><td colspan='2'>[[1ndn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDN FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ndn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndn OCA], [https://pdbe.org/1ndn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ndn RCSB], [https://www.ebi.ac.uk/pdbsum/1ndn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ndn ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ndn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndn OCA], [http://www.ebi.ac.uk/pdbsum/1ndn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ndn RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Aymani J]] |
| - | '''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''
| + | [[Category: Coll M]] |
| - | | + | [[Category: Rich A]] |
| - | | + | [[Category: Van Boom JH]] |
| - | ==Overview==
| + | [[Category: Van Der Marel GA]] |
| - | The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides, has been determined by x-ray diffraction analysis at 3 A resolution. The molecule adopts a B-DNA conformation, not unlike those found in intact dodecamer DNA molecules crystallized in a somewhat different crystal lattice, despite a gap due to the absence of a phosphate group in the molecule. The helix has a distinct narrow minor groove near the center of the molecule at the AAAA region. This suggests that the internal stabilizing forces due to base stacking and hydrogen-bonding interactions are sufficient to overcome the loss of connectivity associated with the disruption of the covalent backbone of DNA.
| + | [[Category: Wang AH-J]] |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1NDN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2320572 2320572]
| + | |
| - | [[Category: Protein complex]] | + | |
| - | [[Category: Aymani, J.]] | + | |
| - | [[Category: Boom, J H.Van.]]
| + | |
| - | [[Category: Coll, M.]] | + | |
| - | [[Category: Marel, G A.Van Der.]] | + | |
| - | [[Category: Rich, A.]] | + | |
| - | [[Category: Wang, A H.J.]] | + | |
| - | [[Category: b-dna]] | + | |
| - | [[Category: double helix]]
| + | |
| - | [[Category: nicked]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:28:58 2008''
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