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1ngn

From Proteopedia

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{{Seed}}
 
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[[Image:1ngn.png|left|200px]]
 
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==Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4==
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The line below this paragraph, containing "STRUCTURE_1ngn", creates the "Structure Box" on the page.
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<StructureSection load='1ngn' size='340' side='right'caption='[[1ngn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ngn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngn OCA], [https://pdbe.org/1ngn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngn RCSB], [https://www.ebi.ac.uk/pdbsum/1ngn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngn ProSAT]</span></td></tr>
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{{STRUCTURE_1ngn| PDB=1ngn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/1ngn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ngn ConSurf].
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<div style="clear:both"></div>
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===Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4===
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12456671}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12456671 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12456671}}
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==About this Structure==
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1NGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGN OCA].
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==Reference==
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Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4., Wu P, Qiu C, Sohail A, Zhang X, Bhagwat AS, Cheng X, J Biol Chem. 2003 Feb 14;278(7):5285-91. Epub 2002 Nov 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12456671 12456671]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Bhagwat AS]]
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[[Category: Bhagwat, A S.]]
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[[Category: Cheng X]]
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[[Category: Cheng, X.]]
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[[Category: Qiu C]]
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[[Category: Qiu, C.]]
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[[Category: Sohail A]]
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[[Category: Sohail, A.]]
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[[Category: Wu P]]
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[[Category: Wu, P.]]
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[[Category: Zhang X]]
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[[Category: Zhang, X.]]
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[[Category: Mismacth repair in methylated dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:14:07 2008''
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Current revision

Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4

PDB ID 1ngn

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