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1nth

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==Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)==
==Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)==
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<StructureSection load='1nth' size='340' side='right' caption='[[1nth]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='1nth' size='340' side='right'caption='[[1nth]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l2r 1l2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NTH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l2r 1l2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l2q|1l2q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nth OCA], [http://pdbe.org/1nth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nth RCSB], [http://www.ebi.ac.uk/pdbsum/1nth PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nth OCA], [https://pdbe.org/1nth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nth RCSB], [https://www.ebi.ac.uk/pdbsum/1nth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nth ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTMB1_METBA MTMB1_METBA]] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).<ref>PMID:9642198</ref> <ref>PMID:9195968</ref>
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[https://www.uniprot.org/uniprot/MTMB1_METBA MTMB1_METBA] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).<ref>PMID:9642198</ref> <ref>PMID:9195968</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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A new UAG-encoded residue in the structure of a methanogen methyltransferase.,Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK Science. 2002 May 24;296(5572):1462-6. PMID:12029132<ref>PMID:12029132</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1nth" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Pyrrolysine|Pyrrolysine]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
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[[Category: Chan, M K]]
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[[Category: Chan MK]]
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[[Category: Ferguson, T K]]
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[[Category: Ferguson TK]]
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[[Category: Gong, W]]
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[[Category: Gong W]]
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[[Category: Hao, B]]
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[[Category: Hao B]]
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[[Category: James, C M]]
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[[Category: James CM]]
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[[Category: Krzycki, J A]]
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[[Category: Krzycki JA]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)

PDB ID 1nth

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