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1nzg

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[[Image:1nzg.gif|left|200px]]
 
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{{Structure
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==Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine==
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|PDB= 1nzg |SIZE=350|CAPTION= <scene name='initialview01'>1nzg</scene>, resolution 1.60&Aring;
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<StructureSection load='1nzg' size='340' side='right'caption='[[1nzg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1nzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ME:2-O-{2-[2-(DIMETHYLAMINO)ETHOXY]ETHYL}-5-METHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>3ME</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzg OCA], [https://pdbe.org/1nzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzg RCSB], [https://www.ebi.ac.uk/pdbsum/1nzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzg ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Egli M]]
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[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs.
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[[Category: Manoharan M]]
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[[Category: Minasov G]]
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==About this Structure==
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[[Category: Prakash TP]]
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1NZG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA].
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[[Category: Prhavc M]]
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==Reference==
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2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12790517 12790517]
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[[Category: Protein complex]]
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[[Category: Egli, M.]]
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[[Category: Manoharan, M.]]
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[[Category: Minasov, G.]]
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[[Category: Prakash, T P.]]
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[[Category: Prhavc, M.]]
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[[Category: 2'-modified oligonucleotide]]
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[[Category: a-dna]]
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[[Category: crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:43 2008''
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Current revision

Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine

PDB ID 1nzg

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