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1obp

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[[Image:1obp.gif|left|200px]]
 
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{{Structure
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==ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA==
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|PDB= 1obp |SIZE=350|CAPTION= <scene name='initialview01'>1obp</scene>, resolution 2.00&Aring;
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<StructureSection load='1obp' size='340' side='right'caption='[[1obp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
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<table><tr><td colspan='2'>[[1obp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OBP FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1obp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1obp OCA], [https://pdbe.org/1obp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1obp RCSB], [https://www.ebi.ac.uk/pdbsum/1obp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1obp ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1obp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1obp OCA], [http://www.ebi.ac.uk/pdbsum/1obp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1obp RCSB]</span>
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== Function ==
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[https://www.uniprot.org/uniprot/OBP_BOVIN OBP_BOVIN] This protein binds a wide variety of chemical odorants.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1obp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1obp ConSurf].
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<div style="clear:both"></div>
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'''ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA'''
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==See Also==
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*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Odorant binding protein (OBP) is the major odorant binding component of mammalian nasal mucosa. The two structures of bovine OBP reported in this paper (one crystallized as purified and one soaked in the presence of a selenium-containing odorant) show that: (i) the OBP dimer is composed of two compact domains related by an approximate two-fold axis of symmetry; (ii) between residues 122 and 123 the polypeptide chains cross from one domain to the other such that each domain is formed by residues from both monomers; (iii) purified OBP already contains two bound odorant molecules (one per monomer)-odorant binding occurs by replacement of these molecules with the added odorant; and (iv) the structure of the odorant binding site can explain OBP's extraordinarily broad odorant specificity.
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==About this Structure==
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1OBP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBP OCA].
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==Reference==
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The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition., Bianchet MA, Bains G, Pelosi P, Pevsner J, Snyder SH, Monaco HL, Amzel LM, Nat Struct Biol. 1996 Nov;3(11):934-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901871 8901871]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cambillau, C.]]
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[[Category: Cambillau C]]
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[[Category: Tegoni, M.]]
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[[Category: Tegoni M]]
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[[Category: lipocalin]]
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[[Category: nose]]
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[[Category: odorant-binding protein]]
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[[Category: olfaction]]
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[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:52 2008''
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Current revision

ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA

PDB ID 1obp

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