1omo

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{{Seed}}
 
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[[Image:1omo.png|left|200px]]
 
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==alanine dehydrogenase dimer w/bound NAD (archaeal)==
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The line below this paragraph, containing "STRUCTURE_1omo", creates the "Structure Box" on the page.
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<StructureSection load='1omo' size='340' side='right'caption='[[1omo]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1omo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OMO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1omo| PDB=1omo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1omo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omo OCA], [https://pdbe.org/1omo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1omo RCSB], [https://www.ebi.ac.uk/pdbsum/1omo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1omo ProSAT]</span></td></tr>
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</table>
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===alanine dehydrogenase dimer w/bound NAD (archaeal)===
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== Function ==
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[https://www.uniprot.org/uniprot/ALADH_ARCFU ALADH_ARCFU] Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate. Its physiological role is not known. Can not use NADP(+) instead of NAD(+) as a cosubstrate. In the deamination direction, can also efficiently use L-2-aminobutyrate as substrate. In the reductive amination direction, also exhibits high activity with 2-oxobutyrate and oxaloacetate as substrate. In contrast to bacterial homologs, does not exhibit any ornithine cyclodeaminase activity.[HAMAP-Rule:MF_00935]<ref>PMID:15516582</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15313611 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/1omo_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15313611}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1OMO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMO OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1omo ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin., Gallagher DT, Monbouquette HG, Schroder I, Robinson H, Holden MJ, Smith NN, J Mol Biol. 2004 Sep 3;342(1):119-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15313611 15313611]
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<references/>
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__TOC__
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Crystallization and phasing of alanine dehydrogenase from Archaeoglobus fulgidus., Smith N, Mayhew M, Robinson H, Heroux A, Charlton D, Holden MJ, Gallagher DT, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2328-31. Epub 2003, Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14646110 14646110]
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</StructureSection>
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[[Category: Alanine dehydrogenase]]
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[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gallagher, D T.]]
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[[Category: Gallagher DT]]
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[[Category: Holden, M J.]]
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[[Category: Holden MJ]]
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[[Category: Monbouquette, H G.]]
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[[Category: Monbouquette HG]]
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[[Category: Schroeder, I.]]
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[[Category: Schroeder I]]
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[[Category: Smith, N N.]]
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[[Category: Smith NN]]
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[[Category: Beta-sandwich-dimer]]
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[[Category: Human mu crystallin homolog]]
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[[Category: Human thyroid-hormone-binder homolog]]
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[[Category: Rossmann-fold nad domain]]
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[[Category: Two-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:52:12 2008''
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Current revision

alanine dehydrogenase dimer w/bound NAD (archaeal)

PDB ID 1omo

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