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1on9

From Proteopedia

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[[Image:1on9.png|left|200px]]
 
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{{STRUCTURE_1on9| PDB=1on9 | SCENE= }}
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==Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound)==
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<StructureSection load='1on9' size='340' side='right'caption='[[1on9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1on9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii Propionibacterium freudenreichii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ON9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12743028}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MCA:METHYLMALONYL-COENZYME+A'>MCA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1on9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on9 OCA], [https://pdbe.org/1on9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1on9 RCSB], [https://www.ebi.ac.uk/pdbsum/1on9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1on9 ProSAT]</span></td></tr>
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[[1on9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii Propionibacterium freudenreichii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON9 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/12S_PROFR 12S_PROFR] The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin.
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<ref group="xtra">PMID:012743028</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Methylmalonyl-CoA carboxytransferase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1on9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1on9 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Propionibacterium freudenreichii]]
[[Category: Propionibacterium freudenreichii]]
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[[Category: Carey, P R.]]
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[[Category: Carey PR]]
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[[Category: Hall, P R.]]
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[[Category: Hall PR]]
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[[Category: Pustai-Carey, M.]]
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[[Category: Pustai-Carey M]]
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[[Category: Rivera-Hainaj, R E.]]
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[[Category: Rivera-Hainaj RE]]
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[[Category: Wang, Y F.]]
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[[Category: Wang Y-F]]
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[[Category: Yee, V C.]]
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[[Category: Yee VC]]
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[[Category: Zheng, X.]]
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[[Category: Zheng X]]
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[[Category: Carboxyl transferase]]
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[[Category: Domain duplication]]
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[[Category: Multienzyme complex]]
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[[Category: Transcarboxylase]]
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[[Category: Transferase]]
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Current revision

Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound)

PDB ID 1on9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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