1osh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:02, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1osh.png|left|200px]]
 
-
<!--
+
==A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR==
-
The line below this paragraph, containing "STRUCTURE_1osh", creates the "Structure Box" on the page.
+
<StructureSection load='1osh' size='340' side='right'caption='[[1osh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1osh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEX:METHYL+3-{3-[(CYCLOHEXYLCARBONYL){[4-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE'>FEX</scene></td></tr>
-
{{STRUCTURE_1osh| PDB=1osh | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osh OCA], [https://pdbe.org/1osh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osh RCSB], [https://www.ebi.ac.uk/pdbsum/1osh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osh ConSurf].
 +
<div style="clear:both"></div>
-
===A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR===
+
==See Also==
-
 
+
*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12718892}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 12718892 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_12718892}}
+
-
 
+
-
==About this Structure==
+
-
1OSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA].
+
-
 
+
-
==Reference==
+
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR., Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM, Mol Cell. 2003 Apr;11(4):1079-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12718892 12718892]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Alvarez, J G.A.]]
+
[[Category: Alvarez JGA]]
-
[[Category: Anisfeld, A M.]]
+
[[Category: Anisfeld AM]]
-
[[Category: Bowman, M E.]]
+
[[Category: Bowman ME]]
-
[[Category: Downes, M.]]
+
[[Category: Downes M]]
-
[[Category: Edwards, P A.]]
+
[[Category: Edwards PA]]
-
[[Category: Evans, R M.]]
+
[[Category: Evans RM]]
-
[[Category: Ferrer, J L.]]
+
[[Category: Ferrer J-L]]
-
[[Category: Hogenesch, J B.]]
+
[[Category: Hogenesch JB]]
-
[[Category: Hughes, R.]]
+
[[Category: Hughes R]]
-
[[Category: Kast-Woelbern, H R.]]
+
[[Category: Kast-Woelbern HR]]
-
[[Category: Nicolaou, K C.]]
+
[[Category: Nicolaou KC]]
-
[[Category: Noel, J P.]]
+
[[Category: Noel JP]]
-
[[Category: Roecker, A J.]]
+
[[Category: Roecker AJ]]
-
[[Category: Rosenfeld, J M.]]
+
[[Category: Rosenfeld JM]]
-
[[Category: Verdecia, M A.]]
+
[[Category: Verdecia MA]]
-
[[Category: Ligand binding domain]]
+
-
[[Category: Nuclear receptor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:12:42 2008''
+

Current revision

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

PDB ID 1osh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1osh"
Personal tools