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1osu

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[[Image:1osu.jpg|left|200px]]<br /><applet load="1osu" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1osu, resolution 1.400&Aring;" />
 
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'''STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS'''<br />
 
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==Overview==
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==STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS==
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The crystal structure of the RNA fragment, 5'-r(UUCGCG)-3', has been determined at 1.4 A resolution by a combination of single isomorphous replacement and molecular search methods. The 3'-terminal CGCG portion of the hexamer engages in Watson-Crick hydrogen bonding while the 5'-terminal UU-overhang forms novel Hoogsteen-like U.U self-base pairs with the overhang of an adjacent duplex. The U.U pairs display a single conventional hydrogen bond between O4 (U1) and N3 (U8) and a CH-O hydrogen bond between C5-H (U1) and O4 (U8), through the Hoogsteen face of the pyrimidine base U1. This unusual arrangement of one of the bases results in a trans U.U pair on antiparallel strands in contrast to the usual cis base pairs. The structure emphasizes the pronounced polymorphism of U.U pairs and has implications for folding of RNA molecules.
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<StructureSection load='1osu' size='340' side='right'caption='[[1osu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1osu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSU FirstGlance]. <br>
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1OSU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSU OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osu OCA], [https://pdbe.org/1osu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osu RCSB], [https://www.ebi.ac.uk/pdbsum/1osu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osu ProSAT]</span></td></tr>
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==Reference==
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</table>
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The structure of r(UUCGCG) has a 5'-UU-overhang exhibiting Hoogsteen-like trans U.U base pairs., Wahl MC, Rao ST, Sundaralingam M, Nat Struct Biol. 1996 Jan;3(1):24-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8548450 8548450]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Rao, S T.]]
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[[Category: Large Structures]]
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[[Category: Sundaralingam, M.]]
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[[Category: Rao ST]]
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[[Category: Wahl, M C.]]
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[[Category: Sundaralingam M]]
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[[Category: 5'-uu-overhang]]
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[[Category: Wahl MC]]
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[[Category: a-rna]]
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[[Category: double helix]]
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[[Category: mismatched]]
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[[Category: nicked]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:21:18 2008''
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Current revision

STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS

PDB ID 1osu

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