1ou4

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{{Seed}}
 
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[[Image:1ou4.png|left|200px]]
 
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==Native PNP +Talo==
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The line below this paragraph, containing "STRUCTURE_1ou4", creates the "Structure Box" on the page.
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<StructureSection load='1ou4' size='340' side='right'caption='[[1ou4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ou4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OU4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MP:6-METHYLPURINE'>6MP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1ou4| PDB=1ou4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ou4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ou4 OCA], [https://pdbe.org/1ou4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ou4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ou4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ou4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEOD_ECOLI DEOD_ECOLI] Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.[HAMAP-Rule:MF_01627]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/1ou4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ou4 ConSurf].
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<div style="clear:both"></div>
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===Native PNP +Talo===
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==See Also==
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14700625}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14700625 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14700625}}
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==About this Structure==
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1OU4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OU4 OCA].
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==Reference==
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Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system., Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA 3rd, Sorscher EJ, Townes TM, Waud WR, Ealick SE, Chem Biol. 2003 Dec;10(12):1173-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14700625 14700625]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Allan PW]]
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[[Category: Allan, P W.]]
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[[Category: Anand R]]
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[[Category: Anand, R.]]
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[[Category: Bennett EM]]
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[[Category: Bennett, E M.]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E.]]
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[[Category: Hassan AE]]
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[[Category: Hassan, A E.]]
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[[Category: McPherson DT]]
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[[Category: McPherson, D T.]]
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[[Category: Parker WB]]
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[[Category: Parker, W B.]]
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[[Category: Secrist JA]]
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[[Category: Secrist, J A.]]
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[[Category: Sorscher EJ]]
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[[Category: Sorscher, E J.]]
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[[Category: Native]]
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[[Category: Talo]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:54:00 2008''
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Current revision

Native PNP +Talo

PDB ID 1ou4

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