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1p6i
From Proteopedia
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| - | [[Image:1p6i.jpg|left|200px]]<br /><applet load="1p6i" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1p6i, resolution 1.90Å" /> | ||
| - | '''Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound'''<br /> | ||
| - | == | + | ==Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound== |
| - | + | <StructureSection load='1p6i' size='340' side='right'caption='[[1p6i]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1p6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DP3:N-{(4S)-4-AMINO-5-[(2-AMINOETHYL)AMINO]PENTYL}-N-NITROGUANIDINE'>DP3</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6i OCA], [https://pdbe.org/1p6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6i RCSB], [https://www.ebi.ac.uk/pdbsum/1p6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6i_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6i ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | + | [[Category: Flinspach ML]] | |
| - | [[Category: Flinspach | + | [[Category: Gomez-Vidal JA]] |
| - | [[Category: Gomez-Vidal | + | [[Category: Hah J-M]] |
| - | [[Category: Hah | + | [[Category: Huang H]] |
| - | [[Category: Huang | + | [[Category: Jamal J]] |
| - | [[Category: Jamal | + | [[Category: Li H]] |
| - | [[Category: Li | + | [[Category: Litzinger EA]] |
| - | [[Category: Litzinger | + | [[Category: Poulos TL]] |
| - | [[Category: Poulos | + | [[Category: Silverman RB]] |
| - | [[Category: Silverman | + | [[Category: Yang W]] |
| - | [[Category: Yang | + | |
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Current revision
Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
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Categories: Large Structures | Rattus norvegicus | Flinspach ML | Gomez-Vidal JA | Hah J-M | Huang H | Jamal J | Li H | Litzinger EA | Poulos TL | Silverman RB | Yang W
