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1pcx

From Proteopedia

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[[Image:1pcx.png|left|200px]]
 
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{{STRUCTURE_1pcx| PDB=1pcx | SCENE= }}
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==Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide from the SNARE protein Bet1==
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<StructureSection load='1pcx' size='340' side='right'caption='[[1pcx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide from the SNARE protein Bet1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pcx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PCX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12941276}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pcx OCA], [https://pdbe.org/1pcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pcx RCSB], [https://www.ebi.ac.uk/pdbsum/1pcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pcx ProSAT]</span></td></tr>
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[[1pcx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCX OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SEC24_YEAST SEC24_YEAST] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles. The SEC23/24 complex is also involved in internalisation of plasma membrane proteins like the maltose transporter.<ref>PMID:8548805</ref> <ref>PMID:9023343</ref> <ref>PMID:9428766</ref> <ref>PMID:10198022</ref> <ref>PMID:10753972</ref> <ref>PMID:10749860</ref> <ref>PMID:11086000</ref> <ref>PMID:10720463</ref> <ref>PMID:10712514</ref> <ref>PMID:12941277</ref> <ref>PMID:12655150</ref> <ref>PMID:14627716</ref> <ref>PMID:16269340</ref>
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<ref group="xtra">PMID:012941276</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/1pcx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pcx ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Bickford, L C.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Goldberg, J.]]
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[[Category: Bickford LC]]
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[[Category: Mossessova, E.]]
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[[Category: Goldberg J]]
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[[Category: Transport protein]]
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[[Category: Mossessova E]]

Current revision

Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide from the SNARE protein Bet1

PDB ID 1pcx

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