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1pe8

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[[Image:1pe8.jpg|left|200px]]
 
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{{Structure
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==Thermolysin with monocyclic inhibitor==
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|PDB= 1pe8 |SIZE=350|CAPTION= <scene name='initialview01'>1pe8</scene>, resolution 1.80&Aring;
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<StructureSection load='1pe8' size='340' side='right'caption='[[1pe8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BR5:2-ETHOXYETHYLPHOSPHINATE'>BR5</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LEN:3-METHYLBUTAN-1-AMINE'>LEN</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1pe8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PE8 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR5:2-ETHOXYETHYLPHOSPHINATE'>BR5</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LEN:3-METHYLBUTAN-1-AMINE'>LEN</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe8 OCA], [https://pdbe.org/1pe8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pe8 RCSB], [https://www.ebi.ac.uk/pdbsum/1pe8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pe8 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1pe5|1PE5]], [[1pe7|1PE7]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe8 OCA], [http://www.ebi.ac.uk/pdbsum/1pe8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pe8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1pe8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pe8 ConSurf].
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<div style="clear:both"></div>
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'''Thermolysin with monocyclic inhibitor'''
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==See Also==
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*[[Thermolysin 3D structures|Thermolysin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1PE8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE8 OCA].
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[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thermolysin]]
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[[Category: Bartlett PA]]
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[[Category: Bartlett, P A.]]
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[[Category: Juers D]]
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[[Category: Juers, D.]]
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[[Category: Matthews BW]]
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[[Category: Matthews, B W.]]
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[[Category: Pyun H-J]]
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[[Category: Pyun, H J.]]
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[[Category: hydrolase]]
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[[Category: metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:58:28 2008''
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Current revision

Thermolysin with monocyclic inhibitor

PDB ID 1pe8

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