1pw4

<table><tr><td colspan='2'>[[1pw4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PW4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PW4 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glpT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pw4 OCA], [http://pdbe.org/1pw4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pw4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pw4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pw4 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GLPT_ECOLI GLPT_ECOLI]] Responsible for glycerol-3-phosphate uptake.

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== Publication Abstract from PubMed ==

The major facilitator superfamily represents the largest group of secondary membrane transporters in the cell. Here we report the 3.3 angstrom resolution structure of a member of this superfamily, GlpT, which transports glycerol-3-phosphate into the cytoplasm and inorganic phosphate into the periplasm. The amino- and carboxyl-terminal halves of the protein exhibit a pseudo two-fold symmetry. Closed off to the periplasm, a centrally located substrate-translocation pore contains two arginines at its closed end, which comprise the substrate-binding site. Upon substrate binding, the protein adopts a more compact conformation. We propose that GlpT operates by a single-binding site, alternating-access mechanism through a rocker-switch type of movement.

Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli.,Huang Y, Lemieux MJ, Song J, Auer M, Wang DN Science. 2003 Aug 1;301(5633):616-20. PMID:12893936<ref>PMID:12893936</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1pw4" style="background-color:#fffaf0;"></div>

==See Also==

*[[Major Facilitators|Major Facilitators]]

== References ==

<references/>

[[Category: Bacillus coli migula 1895]]

[[Category: Auer, M]]

[[Category: Huang, Y]]

[[Category: Lemieux, M J]]

[[Category: Song, J]]

[[Category: Wang, D N]]

[[Category: Transporter]]