This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1q07

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:11, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1q07.gif|left|200px]]
 
-
<!--
+
==Crystal structure of the Au(I) form of E. coli CueR, a copper efflux regulator==
-
The line below this paragraph, containing "STRUCTURE_1q07", creates the "Structure Box" on the page.
+
<StructureSection load='1q07' size='340' side='right'caption='[[1q07]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1q07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q07 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-
{{STRUCTURE_1q07| PDB=1q07 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q07 OCA], [https://pdbe.org/1q07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q07 RCSB], [https://www.ebi.ac.uk/pdbsum/1q07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q07 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CUER_ECOLI CUER_ECOLI] Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations.<ref>PMID:10915804</ref> <ref>PMID:11399769</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/1q07_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q07 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of the Au(I) form of E. coli CueR, a copper efflux regulator'''
+
==See Also==
-
 
+
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1Q07 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q07 OCA].
+
-
 
+
-
==Reference==
+
-
Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR., Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A, Science. 2003 Sep 5;301(5638):1383-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12958362 12958362]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Changela, A.]]
+
[[Category: Changela A]]
-
[[Category: Chen, K.]]
+
[[Category: Chen K]]
-
[[Category: Halloran, T V.O.]]
+
[[Category: Holschen J]]
-
[[Category: Holschen, J.]]
+
[[Category: Mondragon A]]
-
[[Category: Mondragon, A.]]
+
[[Category: O'Halloran TV]]
-
[[Category: Outten, C E.]]
+
[[Category: Outten CE]]
-
[[Category: Xue, Y.]]
+
[[Category: Xue Y]]
-
[[Category: Copper efflux regulator]]
+
-
[[Category: Merr family transcriptional regulator]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:42:27 2008''
+

Current revision

Crystal structure of the Au(I) form of E. coli CueR, a copper efflux regulator

PDB ID 1q07

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q07"
Personal tools