1q1f

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[[Image:1q1f.jpg|left|200px]]
 
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<!--The below Structure Template creates the "Structure Box" on the page. It is automatically created and periodically refreshed. All changes to the Structure Template will be lost EXCEPT for changes in the PDB parameter (setting the PDB file loaded) or the SCENE parameter (setting the initial scene to display when the page is loaded). -->
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==Crystal structure of murine neuroglobin==
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<!-- STRUCTURE TEMPLATE BEGIN -->
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<StructureSection load='1q1f' size='340' side='right'caption='[[1q1f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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{{Structure
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== Structural highlights ==
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|PDB= 1q1f |SIZE=350|CAPTION= <scene name='initialview01'>1q1f</scene>, resolution 1.50&Aring;
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<table><tr><td colspan='2'>[[1q1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1F FirstGlance]. <br>
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|SITE=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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|ACTIVITY=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1f OCA], [https://pdbe.org/1q1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1f RCSB], [https://www.ebi.ac.uk/pdbsum/1q1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1f ProSAT]</span></td></tr>
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|GENE= NGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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</table>
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|DOMAIN=
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== Function ==
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|RELATEDENTRY=
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[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1f OCA], [http://www.ebi.ac.uk/pdbsum/1q1f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q1f RCSB]</span>
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== Evolutionary Conservation ==
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}}
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1f ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of murine neuroglobin'''
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==See Also==
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*[[Neuroglobin|Neuroglobin]]
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== References ==
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==Overview==
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<references/>
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Neuroglobin, a recently discovered globin predominantly expressed in neuronal tissue of vertebrates, binds small, gaseous ligands at the sixth coordination position of the heme iron. In the absence of an exogenous ligand, the distal histidine (His64) binds to the heme iron in the ferrous and ferric states. The crystal structure of murine ferric (met) neuroglobin at 1.5 A reveals interesting features relevant to the ligand binding mechanism. Only weak selectivity is observed for the two possible heme orientations, the occupancy ratio being 70:30. Two small internal cavities are present on the heme distal side, which enable the His64(E7) side chain to move out of the way upon exogenous ligand binding. Moreover, a third, huge cavity (volume approximately 290 A3) connecting both sides of the heme, is open towards the exterior and provides a potential passageway for ligands. The CD and EF corners exhibit substantial flexibility, which may assist ligands in entering the protein and accessing the active site. Based on this high-resolution structure, further structure-function studies can be planned to elucidate the role of neuroglobin in physiological responses to hypoxia.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1Q1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1F OCA].
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==Reference==
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The structure of murine neuroglobin: Novel pathways for ligand migration and binding., Vallone B, Nienhaus K, Brunori M, Nienhaus GU, Proteins. 2004 Jul 1;56(1):85-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15162488 15162488]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Brunori M]]
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[[Category: Brunori, M.]]
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[[Category: Matthes K]]
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[[Category: Matthes, K.]]
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[[Category: Nienhaus GU]]
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[[Category: Nienhaus, G U.]]
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[[Category: Nienhaus K]]
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[[Category: Nienhaus, K.]]
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[[Category: Vallone B]]
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[[Category: Vallone, B.]]
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[[Category: Globin fold]]
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[[Category: Heme protein]]
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[[Category: Neuroglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Apr 7 20:51:23 2008''
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Current revision

Crystal structure of murine neuroglobin

PDB ID 1q1f

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