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1q3h

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{{Seed}}
 
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[[Image:1q3h.png|left|200px]]
 
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<!--
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==mouse CFTR NBD1 with AMP.PNP==
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The line below this paragraph, containing "STRUCTURE_1q3h", creates the "Structure Box" on the page.
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<StructureSection load='1q3h' size='340' side='right'caption='[[1q3h]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q3h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1q3h| PDB=1q3h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3h OCA], [https://pdbe.org/1q3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3h RCSB], [https://www.ebi.ac.uk/pdbsum/1q3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CFTR_MOUSE CFTR_MOUSE] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3h ConSurf].
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<div style="clear:both"></div>
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===mouse CFTR NBD1 with AMP.PNP===
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==See Also==
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14685259}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14685259 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_14685259}}
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==About this Structure==
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1Q3H is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3H OCA].
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==Reference==
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<ref group="xtra">PMID:14685259</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Buchanan, S G.]]
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[[Category: Buchanan SG]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Conners, K.]]
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[[Category: Conners K]]
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[[Category: Dickey, M.]]
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[[Category: Dickey M]]
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[[Category: Dorwart, M.]]
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[[Category: Dorwart M]]
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[[Category: Fowler, R.]]
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[[Category: Fowler R]]
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[[Category: Gao, X.]]
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[[Category: Gao X]]
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[[Category: Guggino, W B.]]
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[[Category: Guggino WB]]
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[[Category: Hendrickson, W A.]]
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[[Category: Hendrickson WA]]
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[[Category: Lewis, H A.]]
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[[Category: Lewis HA]]
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[[Category: Abc transporter nucleotide binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:06:00 2009''
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Current revision

mouse CFTR NBD1 with AMP.PNP

PDB ID 1q3h

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