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1q7s

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[[Image:1q7s.jpg|left|200px]]
 
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==Crystal structure of bit1==
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The line below this paragraph, containing "STRUCTURE_1q7s", creates the "Structure Box" on the page.
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<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
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{{STRUCTURE_1q7s| PDB=1q7s | SCENE= }}
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</table>
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== Function ==
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'''Crystal structure of bit1'''
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[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Peptidyl-tRNA hydrolase (Pth) activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. Here we report the crystallographic structure of the Homo sapiens Pth2 at a 2.0-A resolution as well as its catalytic properties. In contrast to the structure of Escherichia coli Pth, H. sapiens Pth2 has an alpha/beta fold with a four-stranded antiparallel beta-sheet in its core surrounded by two alpha-helices on each side. This arrangement of secondary structure elements generates a fold not previously reported. Its catalytic efficiency is comparable with that reported for the archaeal Sulfolobus solfataricus Pth2 and higher than that of the bacterial E. coli Pth. Several lines of evidence target the active site to two close loops with highly conserved residues. This active site architecture is unrelated to that of E. coli Pth. In addition, intermolecular contacts in the crystal asymmetric unit cell suggest a likely surface for protein-protein interactions related to the Pth2-mediated apoptosis.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7s_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1Q7S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].
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Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity., De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J, J Biol Chem. 2004 Feb 27;279(9):8111-5. Epub 2003 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14660562 14660562]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jan, Y.]]
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[[Category: De Pereda JM]]
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[[Category: Pascual, J.]]
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[[Category: Jan Y]]
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[[Category: Pereda, J M.De.]]
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[[Category: Pascual J]]
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[[Category: Ruoslahti, E.]]
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[[Category: Ruoslahti E]]
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[[Category: Schimmel, P.]]
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[[Category: Schimmel P]]
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[[Category: Waas, W F.]]
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[[Category: Waas WF]]
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[[Category: Apoptosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:58:28 2008''
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Current revision

Crystal structure of bit1

PDB ID 1q7s

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