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1qpr

From Proteopedia

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{{Seed}}
 
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[[Image:1qpr.png|left|200px]]
 
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==QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP==
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The line below this paragraph, containing "STRUCTURE_1qpr", creates the "Structure Box" on the page.
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<StructureSection load='1qpr' size='340' side='right'caption='[[1qpr]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qpr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QPR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PHT:PHTHALIC+ACID'>PHT</scene>, <scene name='pdbligand=PPC:5-PHOSPHORIBOSYL-1-(BETA-METHYLENE)+PYROPHOSPHATE'>PPC</scene></td></tr>
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{{STRUCTURE_1qpr| PDB=1qpr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qpr OCA], [https://pdbe.org/1qpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qpr RCSB], [https://www.ebi.ac.uk/pdbsum/1qpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qpr ProSAT], [https://www.topsan.org/Proteins/TBSGC/1qpr TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NADC_MYCTU NADC_MYCTU] Involved in the catabolism of quinolinic acid (QA) (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/1qpr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qpr ConSurf].
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<div style="clear:both"></div>
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===QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP===
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9862811}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9862811 is the PubMed ID number.
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Grubmeyer C]]
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{{ABSTRACT_PUBMED_9862811}}
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[[Category: Sacchettini JC]]
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[[Category: Sharma V]]
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==About this Structure==
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1QPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPR OCA].
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==Reference==
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Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target., Sharma V, Grubmeyer C, Sacchettini JC, Structure. 1998 Dec 15;6(12):1587-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9862811 9862811]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Grubmeyer, C.]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sharma, V.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: De novo nad biosynthesis]]
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[[Category: Phosphoribosyltransferase]]
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[[Category: Protein structure initiative]]
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[[Category: Prpp]]
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[[Category: Prtase]]
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[[Category: Psi]]
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[[Category: Quinolinic acid]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:34:14 2008''
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Current revision

QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP

PDB ID 1qpr

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