1qqh

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[[Image:1qqh.gif|left|200px]]
 
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==2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1qqh", creates the "Structure Box" on the page.
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<StructureSection load='1qqh' size='340' side='right'caption='[[1qqh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqh OCA], [https://pdbe.org/1qqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqh RCSB], [https://www.ebi.ac.uk/pdbsum/1qqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqh ProSAT]</span></td></tr>
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{{STRUCTURE_1qqh| PDB=1qqh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV18 VE2_HPV18] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqh ConSurf].
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<div style="clear:both"></div>
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'''2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN'''
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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__TOC__
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==Overview==
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</StructureSection>
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The papillomavirus E2 protein regulates viral transcription and DNA replication through interactions with cellular and viral proteins. The amino-terminal activation domain, which represents a protein class whose structural themes are poorly understood, contains key residues that mediate these functional contacts. The crystal structure of a protease-resistant core of the human papillomavirus type 18 E2 activation domain reveals a novel fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet framework. The protein surface shows extensive overlap of determinants for replication and transcription. The structure broadens the concept of activators to include proteins with potentially malleable, but certainly ordered, structures.
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==About this Structure==
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1QQH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQH OCA].
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==Reference==
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Crystal structure of the human papillomavirus type 18 E2 activation domain., Harris SF, Botchan MR, Science. 1999 Jun 4;284(5420):1673-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356398 10356398]
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[[Category: Human papillomavirus type 18]]
[[Category: Human papillomavirus type 18]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Botchan, M R.]]
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[[Category: Botchan MR]]
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[[Category: Harris, S F.]]
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[[Category: Harris SF]]
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[[Category: Amphipathic helix]]
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[[Category: Cashew/kidney shape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:35:14 2008''
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Current revision

2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN

PDB ID 1qqh

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