1qqh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:16, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1qqh.png|left|200px]]
 
-
<!--
+
==2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN==
-
The line below this paragraph, containing "STRUCTURE_1qqh", creates the "Structure Box" on the page.
+
<StructureSection load='1qqh' size='340' side='right'caption='[[1qqh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1qqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqh OCA], [https://pdbe.org/1qqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqh RCSB], [https://www.ebi.ac.uk/pdbsum/1qqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqh ProSAT]</span></td></tr>
-
{{STRUCTURE_1qqh| PDB=1qqh | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/VE2_HPV18 VE2_HPV18] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqh ConSurf].
 +
<div style="clear:both"></div>
-
===2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN===
+
==See Also==
-
 
+
*[[Regulatory protein E2|Regulatory protein E2]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10356398}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 10356398 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_10356398}}
+
-
 
+
-
==About this Structure==
+
-
1QQH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQH OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:10356398</ref><references group="xtra"/>
+
[[Category: Human papillomavirus type 18]]
[[Category: Human papillomavirus type 18]]
-
[[Category: Botchan, M R.]]
+
[[Category: Large Structures]]
-
[[Category: Harris, S F.]]
+
[[Category: Botchan MR]]
-
[[Category: Amphipathic helix]]
+
[[Category: Harris SF]]
-
[[Category: Cashew/kidney shape]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:23:21 2009''
+

Current revision

2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN

PDB ID 1qqh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qqh"
Personal tools