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1qrd

From Proteopedia

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{{Seed}}
 
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[[Image:1qrd.png|left|200px]]
 
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<!--
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==QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1qrd", creates the "Structure Box" on the page.
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<StructureSection load='1qrd' size='340' side='right'caption='[[1qrd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qrd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBD:CIBACRON+BLUE'>CBD</scene>, <scene name='pdbligand=DQN:DUROQUINONE'>DQN</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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{{STRUCTURE_1qrd| PDB=1qrd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrd OCA], [https://pdbe.org/1qrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrd RCSB], [https://www.ebi.ac.uk/pdbsum/1qrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO1_RAT NQO1_RAT] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qrd ConSurf].
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<div style="clear:both"></div>
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===QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX===
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==See Also==
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7568029}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7568029 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7568029}}
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==About this Structure==
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1QRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRD OCA].
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==Reference==
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The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction., Li R, Bianchet MA, Talalay P, Amzel LM, Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8846-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7568029 7568029]
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[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
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[[Category: Single protein]]
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[[Category: Amzel LM]]
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[[Category: Amzel, L M.]]
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[[Category: Bianchet MA]]
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[[Category: Bianchet, M A.]]
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[[Category: Li R]]
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[[Category: Li, R.]]
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[[Category: Talalay P]]
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[[Category: Talalay, P.]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:00:43 2008''
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Current revision

QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX

PDB ID 1qrd

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