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1qtw

From Proteopedia

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[[Image:1qtw.png|left|200px]]
 
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{{STRUCTURE_1qtw| PDB=1qtw | SCENE= }}
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==HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV==
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<StructureSection load='1qtw' size='340' side='right'caption='[[1qtw]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
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===HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qtw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10458614}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtw OCA], [https://pdbe.org/1qtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtw RCSB], [https://www.ebi.ac.uk/pdbsum/1qtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtw ProSAT]</span></td></tr>
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[[1qtw]] is a 1 chain structure of [[Endonuclease]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/END4_ECOLI END4_ECOLI] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010458614</ref><ref group="xtra">PMID:012112707</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Cunningham, R P.]]
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[[Category: Large Structures]]
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[[Category: Guan, Y.]]
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[[Category: Cunningham RP]]
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[[Category: Haas, B J.]]
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[[Category: Guan Y]]
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[[Category: Hosfield, D J.]]
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[[Category: Haas BJ]]
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[[Category: Tainer, J A.]]
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[[Category: Hosfield DJ]]
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[[Category: Dna repair enzyme]]
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[[Category: Tainer JA]]
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[[Category: Hydrolase]]
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[[Category: Tim barrel]]
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[[Category: Trinuclear zn cluster]]
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Current revision

HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV

PDB ID 1qtw

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