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1r17

From Proteopedia

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{{Seed}}
 
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[[Image:1r17.png|left|200px]]
 
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==Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)==
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The line below this paragraph, containing "STRUCTURE_1r17", creates the "Structure Box" on the page.
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<StructureSection load='1r17' size='340' side='right'caption='[[1r17]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r17]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R17 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1r17| PDB=1r17 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r17 OCA], [https://pdbe.org/1r17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r17 RCSB], [https://www.ebi.ac.uk/pdbsum/1r17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r17 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDRG_STAEP SDRG_STAEP] Binds to the N-terminus of the B beta-chain of human fibrinogen and thereby interferes with thrombin cleavage and release of fibrinopeptide B, thus interfering with fibrin clot formation. This may hinder host defense against microbial infections.<ref>PMID:11371571</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r17_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r17 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)===
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==See Also==
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*[[Fibrinogen binding protein|Fibrinogen binding protein]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14567919}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14567919 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_14567919}}
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==About this Structure==
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1R17 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA].
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==Reference==
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A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogen., Ponnuraj K, Bowden MG, Davis S, Gurusiddappa S, Moore D, Choe D, Xu Y, Hook M, Narayana SV, Cell. 2003 Oct 17;115(2):217-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14567919 14567919]
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[[Category: Single protein]]
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[[Category: Staphylococcus epidermidis]]
[[Category: Staphylococcus epidermidis]]
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[[Category: Bowden, M G.]]
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[[Category: Bowden MG]]
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[[Category: Choe, D.]]
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[[Category: Choe D]]
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[[Category: Davis, S.]]
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[[Category: Davis S]]
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[[Category: Gurusiddappa, S.]]
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[[Category: Gurusiddappa S]]
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[[Category: Hook, M.]]
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[[Category: Hook M]]
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[[Category: Moore, D.]]
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[[Category: Moore D]]
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[[Category: Narayana, S V.L.]]
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[[Category: Narayana SVL]]
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[[Category: Ponnuraj, K.]]
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[[Category: Ponnuraj K]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Mscramm-ligand complex]]
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[[Category: Sdrg]]
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[[Category: Sdrg-fibrinopeptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:20:41 2008''
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Current revision

Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)

PDB ID 1r17

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