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1rgp

From Proteopedia

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{{Seed}}
 
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[[Image:1rgp.png|left|200px]]
 
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<!--
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==GTPASE-ACTIVATION DOMAIN FROM RHOGAP==
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The line below this paragraph, containing "STRUCTURE_1rgp", creates the "Structure Box" on the page.
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<StructureSection load='1rgp' size='340' side='right'caption='[[1rgp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rgp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RGP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rgp OCA], [https://pdbe.org/1rgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rgp RCSB], [https://www.ebi.ac.uk/pdbsum/1rgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rgp ProSAT]</span></td></tr>
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{{STRUCTURE_1rgp| PDB=1rgp | SCENE= }}
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</table>
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== Function ==
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===GTPASE-ACTIVATION DOMAIN FROM RHOGAP===
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[https://www.uniprot.org/uniprot/RHG01_HUMAN RHG01_HUMAN] GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_9009196}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9009196 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/1rgp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9009196}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rgp ConSurf].
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1RGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGP OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The structure of the GTPase-activating domain from p50rhoGAP., Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF, Nature. 1997 Jan 30;385(6615):458-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9009196 9009196]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barrett, T.]]
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[[Category: Barrett T]]
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[[Category: Dodson, E J.]]
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[[Category: Dodson EJ]]
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[[Category: Dodson, G.]]
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[[Category: Dodson G]]
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[[Category: Eccleston, J F.]]
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[[Category: Eccleston JF]]
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[[Category: Gamblin, S J.]]
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[[Category: Gamblin SJ]]
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[[Category: Ludbrook, S B.]]
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[[Category: Ludbrook SB]]
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[[Category: Musacchio, A.]]
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[[Category: Musacchio A]]
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[[Category: Nurmahomed, K.]]
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[[Category: Nurmahomed K]]
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[[Category: Smerdon, S J.]]
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[[Category: Smerdon SJ]]
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[[Category: Xiao, B.]]
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[[Category: Xiao B]]
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[[Category: G-protein]]
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[[Category: Gap]]
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[[Category: Signal-transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:18:10 2008''
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Current revision

GTPASE-ACTIVATION DOMAIN FROM RHOGAP

PDB ID 1rgp

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