1rkc

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{{Seed}}
 
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[[Image:1rkc.png|left|200px]]
 
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==Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)==
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The line below this paragraph, containing "STRUCTURE_1rkc", creates the "Structure Box" on the page.
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<StructureSection load='1rkc' size='340' side='right'caption='[[1rkc]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rkc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RKC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rkc OCA], [https://pdbe.org/1rkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rkc RCSB], [https://www.ebi.ac.uk/pdbsum/1rkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rkc ProSAT]</span></td></tr>
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{{STRUCTURE_1rkc| PDB=1rkc | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:[https://omim.org/entry/611407 611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11815424</ref> <ref>PMID:16236538</ref> Defects in VCL are the cause of familial hypertrophic cardiomyopathy type 15 (CMH15) [MIM:[https://omim.org/entry/613255 613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:16712796</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:20484056</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/1rkc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rkc ConSurf].
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<div style="clear:both"></div>
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===Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)===
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==See Also==
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*[[Talin 3D structures|Talin 3D structures]]
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*[[Vinculin|Vinculin]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_14702644}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 14702644 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_14702644}}
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==Disease==
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Known disease associated with this structure: Cardiomyopathy, dilated, 1W OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193065 193065]]
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==About this Structure==
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1RKC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKC OCA].
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==Reference==
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Vinculin activation by talin through helical bundle conversion., Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR, Nature. 2004 Jan 8;427(6970):171-5. Epub 2003 Dec 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14702644 14702644]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bois, P R.]]
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[[Category: Bois PR]]
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[[Category: Borgon, R A.]]
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[[Category: Borgon RA]]
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[[Category: Bricogne, G.]]
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[[Category: Bricogne G]]
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[[Category: Evans, G.]]
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[[Category: Evans G]]
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[[Category: Izard, T.]]
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[[Category: Izard T]]
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[[Category: Rush, C L.]]
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[[Category: Rush CL]]
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[[Category: Actin-binding]]
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[[Category: Cytoskeleton]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:24:43 2008''
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Current revision

Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)

PDB ID 1rkc

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