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1rs4

From Proteopedia

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[[Image:1rs4.png|left|200px]]
 
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{{STRUCTURE_1rs4| PDB=1rs4 | SCENE= }}
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==DHNA, 7,8-Dihydroneopterin Aldolase complexed with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-dichlorobenzyl)-benzamide==
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<StructureSection load='1rs4' size='340' side='right'caption='[[1rs4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===DHNA, 7,8-Dihydroneopterin Aldolase complexed with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-dichlorobenzyl)-benzamide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rs4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RS4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15027862}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=45P:3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-(3,5-DICHLOROBENZYL)-BENZAMIDE'>45P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rs4 OCA], [https://pdbe.org/1rs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rs4 RCSB], [https://www.ebi.ac.uk/pdbsum/1rs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rs4 ProSAT]</span></td></tr>
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[[1rs4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RS4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOLB_STAAU FOLB_STAAU] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rs4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rs4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldolase|Aldolase]]
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015027862</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Dihydroneopterin aldolase]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Betz, S F.]]
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[[Category: Betz SF]]
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[[Category: Beutel, B A.]]
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[[Category: Beutel BA]]
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[[Category: Condroski, K R.]]
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[[Category: Condroski KR]]
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[[Category: Harlan, J E.]]
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[[Category: Harlan JE]]
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[[Category: Jakob, C G.]]
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[[Category: Jakob CG]]
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[[Category: Lerner, C G.]]
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[[Category: Lerner CG]]
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[[Category: Magdalinos, P.]]
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[[Category: Magdalinos P]]
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[[Category: McCall, J O.]]
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[[Category: McCall JO]]
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[[Category: Meadows, R P.]]
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[[Category: Meadows RP]]
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[[Category: Merrick, S M.]]
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[[Category: Merrick SM]]
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[[Category: Nienaber, V L.]]
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[[Category: Nienaber VL]]
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[[Category: Sanders, W J.]]
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[[Category: Sanders WJ]]
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[[Category: Severin, J M.]]
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[[Category: Severin JM]]
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[[Category: Stamper, G F.]]
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[[Category: Stamper GF]]
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[[Category: Stoll, V S.]]
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[[Category: Stoll VS]]
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[[Category: Swanson, S J.]]
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[[Category: Swanson SJ]]
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[[Category: Wagner, R.]]
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[[Category: Wagner R]]
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[[Category: Walter, K A.]]
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[[Category: Walter KA]]
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[[Category: Dhna]]
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[[Category: Lyase]]
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Current revision

DHNA, 7,8-Dihydroneopterin Aldolase complexed with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-dichlorobenzyl)-benzamide

PDB ID 1rs4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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