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1rwi

From Proteopedia

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{{Seed}}
 
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[[Image:1rwi.png|left|200px]]
 
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<!--
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==Extracellular domain of Mycobacterium tuberculosis PknD==
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The line below this paragraph, containing "STRUCTURE_1rwi", creates the "Structure Box" on the page.
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<StructureSection load='1rwi' size='340' side='right'caption='[[1rwi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rwi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RWI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_1rwi| PDB=1rwi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwi OCA], [https://pdbe.org/1rwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rwi RCSB], [https://www.ebi.ac.uk/pdbsum/1rwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rwi ProSAT], [https://www.topsan.org/Proteins/TBSGC/1rwi TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PKND_MYCTU PKND_MYCTU] Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia. Phosphorylates the anti-anti-sigma factor homolog Rv0516c, which inhibits binding of Rv0516c to Rv2638, another anti-anti-sigma factor. Can also phosphorylate the FHA domain of Rv1747.<ref>PMID:15987910</ref> <ref>PMID:17242402</ref> <ref>PMID:17411339</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rw/1rwi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rwi ConSurf].
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<div style="clear:both"></div>
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===Extracellular domain of Mycobacterium tuberculosis PknD===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15136047}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15136047 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15136047}}
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==About this Structure==
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1RWI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWI OCA].
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==Reference==
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Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller., Good MC, Greenstein AE, Young TA, Ng HL, Alber T, J Mol Biol. 2004 May 28;339(2):459-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15136047 15136047]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Alber T]]
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[[Category: Alber, T.]]
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[[Category: Good MC]]
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[[Category: Good, M C.]]
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[[Category: Greenstein AE]]
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[[Category: Greenstein, A E.]]
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[[Category: Ng HL]]
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[[Category: Ng, H L.]]
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[[Category: Young TA]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Young, T A.]]
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[[Category: Beta propeller]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:24:27 2008''
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Current revision

Extracellular domain of Mycobacterium tuberculosis PknD

PDB ID 1rwi

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