This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rxv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:26, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1rxv.png|left|200px]]
 
-
{{STRUCTURE_1rxv| PDB=1rxv | SCENE= }}
+
==Crystal Structure of A. Fulgidus FEN-1 bound to DNA==
-
 
+
<StructureSection load='1rxv' size='340' side='right'caption='[[1rxv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
===Crystal Structure of A. Fulgidus FEN-1 bound to DNA===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1rxv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXV FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_14718165}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxv OCA], [https://pdbe.org/1rxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxv RCSB], [https://www.ebi.ac.uk/pdbsum/1rxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxv ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1rxv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXV OCA].
+
== Function ==
 +
[https://www.uniprot.org/uniprot/FEN_ARCFU FEN_ARCFU] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxv ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Endonuclease|Endonuclease]]
+
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:014718165</ref><references group="xtra"/>
+
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
-
[[Category: Chapados, B R.]]
+
[[Category: Large Structures]]
-
[[Category: Han, S.]]
+
[[Category: Chapados BR]]
-
[[Category: Hosfield, D J.]]
+
[[Category: Han S]]
-
[[Category: Qiu, J.]]
+
[[Category: Hosfield DJ]]
-
[[Category: Shen, B.]]
+
[[Category: Qiu J]]
-
[[Category: Tainer, J A.]]
+
[[Category: Shen B]]
-
[[Category: Yelent, B.]]
+
[[Category: Tainer JA]]
-
[[Category: 3' flap binding site]]
+
[[Category: Yelent B]]
-
[[Category: Dna repair]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Helical clamp]]
+
-
[[Category: Helix-3 turn-helix]]
+
-
[[Category: Hydrolase-dna complex]]
+
-
[[Category: Protein-dna complex]]
+

Current revision

Crystal Structure of A. Fulgidus FEN-1 bound to DNA

PDB ID 1rxv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rxv"
Personal tools